H2N2V1, Main, Exploration, bibRecord, 002B11

Ability of temperature-sensitive mutants of the recombinant influenza S/N (H2N1) virus to induce immunity to parental (H0N1 and H2N2) viruses.

Identifieur interne : 002B11 ( Main/Exploration ); précédent : 002B10; suivant : 002B12

Ability of temperature-sensitive mutants of the recombinant influenza S/N (H2N1) virus to induce immunity to parental (H0N1 and H2N2) viruses.

Auteurs : B. Dolezalová ; E. Tu Ková ; M. Stárek ; V. Vonka ; H. Zavadova

Source :

Infection and immunity [ 0019-9567 ] ; 1976.

RBID : pubmed:965084

Descripteurs français

KwdFr :
- Anticorps antiviraux (biosynthèse), Antigènes viraux, Grippe humaine (), Génotype, Humains, Hémagglutinines virales, Mutation, Orthomyxoviridae (immunologie), Poumon (microbiologie), Réplication virale, Sialidase (immunologie), Sous-type H2N2 du virus de la grippe A, Vaccination, Vaccins antigrippaux, Virus de la grippe A (enzymologie), Virus de la grippe A (immunologie).
MESH :
- biosynthèse : Anticorps antiviraux.
- enzymologie : Virus de la grippe A.
- immunologie : Orthomyxoviridae, Sialidase, Virus de la grippe A.
- microbiologie : Poumon.
- Antigènes viraux, Grippe humaine, Génotype, Humains, Hémagglutinines virales, Mutation, Réplication virale, Sous-type H2N2 du virus de la grippe A, Vaccination, Vaccins antigrippaux.

English descriptors

KwdEn :
- Antibodies, Viral (biosynthesis), Antigens, Viral, Genotype, Hemagglutinins, Viral, Humans, Influenza A Virus, H2N2 Subtype, Influenza A virus (enzymology), Influenza A virus (immunology), Influenza Vaccines, Influenza, Human (prevention & control), Lung (microbiology), Mutation, Neuraminidase (immunology), Orthomyxoviridae (immunology), Vaccination, Virus Replication.
MESH :
- chemical , biosynthesis : Antibodies, Viral.
- chemical , immunology : Neuraminidase.
- chemical : Antigens, Viral, Hemagglutinins, Viral, Influenza Vaccines.
- enzymology : Influenza A virus.
- immunology : Influenza A virus, Orthomyxoviridae.
- microbiology : Lung.
- prevention & control : Influenza, Human.
- Genotype, Humans, Influenza A Virus, H2N2 Subtype, Mutation, Vaccination, Virus Replication.

Abstract

The behavior in mice of two thermosensitive (ts) mutants (denoted ts217 and ts700) of the recombinant influenza virus S/N (H2N1) was studied. The parental thermoresistant (tr) virus and both of the mutants were capable of inducing protection against pneumotropic A/Singapore (H2N2) and A/WS (H0N1) challenge viruses. Immunity against the Singapore virus, with which the S/N virus shared the hemagglutinin, developed earlier than against the WS virus, with which the S/N virus shared the neuraminidase. The tr and ts217 viruses were immunologically more active than the ts700 virus. The first two viruses grew markedly better in mouse lungs than did the latter. In the course of ts217 virus replication in vivo, revertants capable of growing at 39 degrees C appeared readily. On the other hand, the ts700 virus proved to be genetically stable. These data seem to provide evidence of a linkage between the stability of the ts phenotype, reproductive capacity in mouse lungs, and immunogenicity in the viruses examined.

PubMed: 965084

Affiliations:

Le document en format XML

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<term>Hemagglutinins, Viral</term>
<term>Humans</term>
<term>Influenza A Virus, H2N2 Subtype</term>
<term>Influenza A virus (enzymology)</term>
<term>Influenza A virus (immunology)</term>
<term>Influenza Vaccines</term>
<term>Influenza, Human (prevention & control)</term>
<term>Lung (microbiology)</term>
<term>Mutation</term>
<term>Neuraminidase (immunology)</term>
<term>Orthomyxoviridae (immunology)</term>
<term>Vaccination</term>
<term>Virus Replication</term>
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<keywords scheme="KwdFr" xml:lang="fr"><term>Anticorps antiviraux (biosynthèse)</term>
<term>Antigènes viraux</term>
<term>Grippe humaine ()</term>
<term>Génotype</term>
<term>Humains</term>
<term>Hémagglutinines virales</term>
<term>Mutation</term>
<term>Orthomyxoviridae (immunologie)</term>
<term>Poumon (microbiologie)</term>
<term>Réplication virale</term>
<term>Sialidase (immunologie)</term>
<term>Sous-type H2N2 du virus de la grippe A</term>
<term>Vaccination</term>
<term>Vaccins antigrippaux</term>
<term>Virus de la grippe A (enzymologie)</term>
<term>Virus de la grippe A (immunologie)</term>
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<term>Hemagglutinins, Viral</term>
<term>Influenza Vaccines</term>
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<term>Humans</term>
<term>Influenza A Virus, H2N2 Subtype</term>
<term>Mutation</term>
<term>Vaccination</term>
<term>Virus Replication</term>
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<term>Humains</term>
<term>Hémagglutinines virales</term>
<term>Mutation</term>
<term>Réplication virale</term>
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<front><div type="abstract" xml:lang="en">The behavior in mice of two thermosensitive (ts) mutants (denoted ts217 and ts700) of the recombinant influenza virus S/N (H2N1) was studied. The parental thermoresistant (tr) virus and both of the mutants were capable of inducing protection against pneumotropic A/Singapore (H2N2) and A/WS (H0N1) challenge viruses. Immunity against the Singapore virus, with which the S/N virus shared the hemagglutinin, developed earlier than against the WS virus, with which the S/N virus shared the neuraminidase. The tr and ts217 viruses were immunologically more active than the ts700 virus. The first two viruses grew markedly better in mouse lungs than did the latter. In the course of ts217 virus replication in vivo, revertants capable of growing at 39 degrees C appeared readily. On the other hand, the ts700 virus proved to be genetically stable. These data seem to provide evidence of a linkage between the stability of the ts phenotype, reproductive capacity in mouse lungs, and immunogenicity in the viruses examined.</div>
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<name sortKey="Tu Kova, E" sort="Tu Kova, E" uniqKey="Tu Kova E" first="E" last="Tu Ková">E. Tu Ková</name>
<name sortKey="Vonka, V" sort="Vonka, V" uniqKey="Vonka V" first="V" last="Vonka">V. Vonka</name>
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Serveur d'exploration H2N2

Ability of temperature-sensitive mutants of the recombinant influenza S/N (H2N1) virus to induce immunity to parental (H0N1 and H2N2) viruses.

Ability of temperature-sensitive mutants of the recombinant influenza S/N (H2N1) virus to induce immunity to parental (H0N1 and H2N2) viruses.

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

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